Endocapillary hypercellularity
A normal appearing glomerulus (left) compared to a glomerulus with endocapillary hypercellularity (right). Note the hypercellular capillary loop (red arrow) compared to the normal capillary lumens (black arrows). This histologic…
Immunofluorescent staining in C3 glomerulopathy
Immunofluorescent staining pattern in a patient with C3 glomerulopathy. There is strong C3 staining in the capillary loops and mesangium. Immunoglobulin staining, such as IgG, is typically absent or at…
Dense deposit disease
Dense deposit disease on electron microscopy in a patient with C3 glomerulopathy. This lesion results from intramembranous transformation of the glomerular basement membrane by sausage-like, “osmiophilic” dense material. Images courtesy…
Membranoproliferative glomerulonephritis
Membranoproliferative pattern of glomerular injury in a patient with C3 glomerulopathy. This pattern of injury typically has endocapillary proliferation, diffuse capillary wall thickening, increased mesangial matrix, and mesangial proliferation visible…
Foam Cells
Clusters of interstitial foam cells (arrows) in a kidney biopsy. These are commonly found in biopsy specimens of patients with Alport syndrome, FSGS, IgA nephropathy, and other proteinuric kidney diseases.…
Acute interstitial nephritis
Acute interstitial nephritis with associated acute tubular injury. There is interstitial edema and the tubules are not back to back as would be expected, due to the inflammatory and lymphocytic…
Focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) in a child presenting with nephrotic syndrome. Image courtesy of Joseph Gaut, MD PhD.
Minimal change disease
Numerous PAS-positive protein reabsorption droplets in the renal tubules of a child with minimal change disease. Image courtesy of Joseph Gaut, MD PhD.
Acute tubular necrosis
Acute tubular necrosis (ATN). Note the tubules are not back-to-back due to interstitial edema (Masson trichrome staining, not shown, did not show appreciable fibrosis). There is blebbing and sloughing of…
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