Mesangial Deposits
Electron microscopy of a biopsy specimen in a patient with IgA nephropathy. Electron dense deposits can be identified in the mesangium (black arrows), which on immunofluorescence would have predominant or…
Perihilar FSGS
Perihilar variant of focal segmental glomerulosclerosis (FSGS). Hyaline deposition and sclerosis occur at the vascular pole of the glomerulus. This variant is believed to be a secondary form of FSGS,…
Glomerulomegaly
A normal glomerulus (left) and hypertrophied glomerulus (glomerulomegaly, right). Glomerulomegaly is an adaptive response to decreased nephron number (e.g. prematurity) and/or increased demand (e.g. obesity). Patients with glomerulomegaly may have…
Segmental glomerulosclerosis in IgA nephropathy
A patient with IgA nephropathy and associated segmental glomerulosclerosis. Images courtesy of Patrick Walker, MD.
Acute interstitial nephritis
A mixed inflammatory cell infiltrate in a child with acute interstitial nephritis. Image courtesy of Patrick Walker, MD.
WBC casts
WBC casts (black arrows) in a biopsy specimen of a patient with acute interstitial nephritis. Images courtesy of Patrick Walker, MD.
Autosomal recessive polycystic kidney disease (ARPKD)
Gross pathology and low-power light microscopy of kidney tissue in a neonate with ARPKD. The kidneys are enlarged but maintain their reniform shape, and are full of microscopic cysts derived…
Simple renal cysts
Microscopic renal cysts. Note the flattened to cuboidal epithelium lining the cysts. Images courtesy of Patrick Walker, MD.
Crescents
A segmental (left, black arrow) and circumferential crescent (right) in a patient with IgA nephropathy. Images courtesy of Patrick Walker, MD.