In this episode, Drs. Amirtha Chinnadurai and Jason Misurac are joined by Dr. Laurel Willig to discuss APOL1-mediated kidney disease in children. They discuss how to conceptualize APOL1 disease, emerging targeted therapies and clinical trials, and practical considerations for genetic testing and counseling families.
00:00 Introduction
01:14 Understanding APOL1 Disease
08:58 APOL1 Phenotypes and Precision Medicine
13:07 Emerging APOL1 Therapies
18:01 Clinical Trials and Pediatric Patients
20:35 Genetic Counseling and APOL1 Testing
Dr. Willig’s ASPN 2026 slides: http://aspneph.org/wp-content/uploads/2026/09/APOL1-Slides-ASPN-2026.pdf
Posted: September 28, 2026