IgA nephropathy

By Brian Stotter | February 3, 2020

IgA nephropathy with crescents. Note the fibrocellular crescent present in this glomerulus extending from the 3 o’clock the 12 o’clock position. Though difficult to appreciate in this image, there is…

SLE nephritis

By Brian Stotter | November 11, 2019

PAS stain of a glomerulus in a patient with SLE nephritis. There is endocapillary and mesangial proliferation, as evidenced by thickened, occlusive capillary loops and increased mesangial cellularity. Note the…

Tubuloreticular inclusions in SLE nephritis

By Brian Stotter | November 11, 2019

Tubuloreticular inclusions in a patient with diffuse proliferative SLE nephritis (SLE class IV). These subcellular structures (dark circular clusters) on transmission electron microscopy are localized to the cytoplasm of endothelial…

Focal and segmental glomerulosclerosis

By Matt McRae | September 27, 2019

Segmental obliteration of the glomerular capillary lumen in a patient with FSGS. Note the sclerotic portion of the glomerular tuft is adherent to Bowman’s capsule. There is proximal tubular hypertrophy,…

Transplant glomerulopathy

By Matt McRae | September 27, 2019

The glomerular capillary bed is thickened, with the presence of double contours reflecting circumferential mesangial expansion into the capillary wall (mesangial interposition). In this biopsy core of chronic allograft injury…