Bill Segar died peacefully at home, in Indianapolis, IN on Feb 1, 2021. He was 97 years old. A very touching tribute to him was written by his son Jeff Segar [a neonatologist and successful researcher in his own right] and published in Pediatric Research. I encourage you to read…
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Life Course Journey of a True Mensch H. William (Bill) Schnaper was the Irene Heinz Green & John LaPorte Given Chair in Pediatric Research and Tenured Professor & Vice Chair, Department of Pediatrics, Feinberg School of Medicine, Northwestern University. He was a graduate of the Baltimore Polytechnic Institute (1967) and…
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It is with great sadness that we announce the passing on October 25, 2020 of John T. Herrin, MBBS, FRACP, 84, former Director of Clinical Services within the Division of Nephrology at Boston Children’s Hospital. After his initial medical training, John left his native Australia and moved to Boston. He spent much of…
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Electron microscopy of a biopsy specimen in a patient with IgA nephropathy. Electron dense deposits can be identified in the mesangium (black arrows), which on immunofluorescence would have predominant or co-dominant IgA staining. Note that although mesangial IgA deposits are classic in IgA nephropathy and IgA vasculitis (former Henoch-Schonlein purpura…
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Perihilar variant of focal segmental glomerulosclerosis (FSGS). Hyaline deposition and sclerosis occur at the vascular pole of the glomerulus. This variant is believed to be a secondary form of FSGS, occurring as an adaptive response to other injuries resulting in loss of functioning nephrons, such as in obesity-related kidney disease.…
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A normal glomerulus (left) and hypertrophied glomerulus (glomerulomegaly, right). Glomerulomegaly is an adaptive response to decreased nephron number (e.g. prematurity) and/or increased demand (e.g. obesity). Patients with glomerulomegaly may have sub-nephrotic or nephrotic-range proteinuria, but other features of nephrotic syndrome are rare. Images courtesy of Patrick Walker, MD.
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A patient with IgA nephropathy and associated segmental glomerulosclerosis. Images courtesy of Patrick Walker, MD.
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Early radiographic changes on left knee X-ray in an infant with hypophosphatemic rickets. There is decreased mineralization of the long bones and splaying, or widening, at the distal femur and proximal tibia, where the metaphyses are located.
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A mixed inflammatory cell infiltrate in a child with acute interstitial nephritis. Image courtesy of Patrick Walker, MD.
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