Matt McRae

Focal and segmental glomerulosclerosis
September 27, 2019

Segmental obliteration of the glomerular capillary lumen in a patient with FSGS. Note the sclerotic portion of the glomerular tuft is adherent to Bowman’s capsule. There is proximal tubular hypertrophy, which can be seen in this condition in response to heavy proteinuria. Image courtesy of Brian Stotter, MD.

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Transplant glomerulopathy
September 27, 2019

The glomerular capillary bed is thickened, with the presence of double contours reflecting circumferential mesangial expansion into the capillary wall (mesangial interposition). In this biopsy core of chronic allograft injury there is minimal interstitial inflammation, primarily localized to the areas of tubular atrophy, and severe interstitial fibrosis.

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Board Review Course 2025
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